Janus Kinase Mutations in Mice Lacking PU.1 and Spi-B Drive B Cell Leukemia through Reactive Oxygen Species-Induced DNA Damage

Precursor B cell acute lymphoblastic leukemia (B-ALL) is caused by genetic lesions in developing B cells that function as drivers for the accumulation of additional mutations in an evolutionary selection process. We investigated secondary drivers of leukemogenesis in a mouse model of B-ALL driven by...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Lim, Michelle, Batista, Carolina R., de Oliveira, Bruno R., Creighton, Rachel, Ferguson, Jacob, Clemmer, Kurt, Knight, Devon, Iansavitchous, James, Mahmood, Danish, Avino, Mariano, DeKoter, Rodney P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7459267/
https://ncbi.nlm.nih.gov/pubmed/32631903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00189-20
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