Driver mutations in Janus kinases in a mouse model of B-cell leukemia induced by deletion of PU.1 and Spi-B

Precursor B-cell acute lymphoblastic leukemia (B-ALL) is associated with recurrent mutations that occur in cancer-initiating cells. There is a need to understand how driver mutations influence clonal evolution of leukemia. The E26-transformation-specific (ETS) transcription factors PU.1 and Spi-B (e...

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Foilsithe in:Blood Adv
Main Authors: Batista, Carolina R., Lim, Michelle, Laramée, Anne-Sophie, Abu-Sardanah, Faisal, Xu, Li S., Hossain, Rajon, Bell, Gillian I., Hess, David A., DeKoter, Rodney P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2018
Ábhair:
Lymphoid Neoplasia
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234372/
https://ncbi.nlm.nih.gov/pubmed/30355579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018019950
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