Negatively charged amino acids in the stalk region of membrane proteins reduce ectodomain shedding

Ectodomain shedding is a post-translational modification mechanism by which the entire extracellular domain of membrane proteins is liberated through juxtamembrane processing. Because shedding rapidly and irreversibly alters the characteristics of cells, this process is properly regulated. However,...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Iwagishi, Ryo, Tanaka, Rika, Seto, Munenosuke, Takagi, Tomoyo, Norioka, Naoko, Ueyama, Tomoe, Kawamura, Teruhisa, Takagi, Junichi, Ogawa, Yoshihiro, Shirakabe, Kyoko
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458810/
https://ncbi.nlm.nih.gov/pubmed/32580944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013758
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