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Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats

PURPOSE: Methamphetamine (METH) abuse is associated with hepatic dysfunction related comorbidities such as HIV, hepatitis C, and polysubstance abuse with acetaminophen-containing opioid formulations. We aimed to develop a bile duct ligation (BDL)-induced hepatic dysfunction model for studying both M...

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Detalhes bibliográficos
Publicado no:J Pharm Pharm Sci
Main Authors: Hambuchen, Michael D., Berquist, Michael D., Simecka, Christy M., McGill, Mitchell R., Gunnell, Melinda G., Hendrickson, Howard P., Owens, S. Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458465/
https://ncbi.nlm.nih.gov/pubmed/31329536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18433/jpps30471
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