Glucose Regulates Microtubule Disassembly and the Dose of Insulin Secretion via Tau Phosphorylation

The microtubule cytoskeleton of pancreatic islet β-cells regulates glucose-stimulated insulin secretion (GSIS). We have reported that the microtubule-mediated movement of insulin vesicles away from the plasma membrane limits insulin secretion. High glucose–induced remodeling of microtubule network f...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Ho, Kung-Hsien, Yang, Xiaodun, Osipovich, Anna B., Cabrera, Over, Hayashi, Mansuo L., Magnuson, Mark A., Gu, Guoqiang, Kaverina, Irina
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2020
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458041/
https://ncbi.nlm.nih.gov/pubmed/32540877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-1186
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