Brain region–specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer’s disease

BACKGROUND: Lipid dysregulation is associated with several key characteristics of Alzheimer’s disease (AD), including amyloid-β and tau neuropathology, neurodegeneration, glucose hypometabolism, as well as synaptic and mitochondrial dysfunction. The β-site amyloid precursor protein cleavage enzyme 1...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Lipids Health Dis
Prif Awduron: Dey, Madhurima, Gunn-Moore, Frank J., Platt, Bettina, Smith, Terry K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2020
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457777/
https://ncbi.nlm.nih.gov/pubmed/32867761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12944-020-01367-8
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