Partial Degradation of Recombinant Antibody Functional Activity During Infant Gastrointestinal Digestion: Implications for Oral Antibody Supplementation

Oral administration of engineered immunoglobulins has the potential to prevent enteric pathogen-induced diarrhea in infants. To prevent infection, these antibodies need to survive functionally intact in the proteolytic environment of the gastrointestinal tract. This research examined both ex vivo an...

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Detalhes bibliográficos
Publicado no:Front Nutr
Main Authors: Sah, Baidya Nath P., Lueangsakulthai, Jiraporn, Kim, Bum Jin, Hauser, Benjamin R., Woo, Yeonhee, Olyaei, Amy, Aloia, Molly, O'Connor, Ann, Scottoline, Brian, Pastey, Manoj K., Dallas, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Nutrition
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456970/
https://ncbi.nlm.nih.gov/pubmed/32923453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnut.2020.00130
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