USF1 defect drives p53 degradation during Helicobacter pylori infection and accelerates gastric carcinogenesis

OBJECTIVE: Helicobacter pylori (Hp) is a major risk factor for gastric cancer (GC). Hp promotes DNA damage and proteasomal degradation of p53, the guardian of genome stability. Hp reduces the expression of the transcription factor USF1 shown to stabilise p53 in response to genotoxic stress. We inves...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Costa, Lionel, Corre, Sébastien, Michel, Valérie, Le Luel, Krysten, Fernandes, Julien, Ziveri, Jason, Jouvion, Gregory, Danckaert, Anne, Mouchet, Nicolas, Da Silva Barreira, David, Torres, Javier, Camorlinga, Margarita, D'Elios, Mario Milco, Fiette, Laurence, De Reuse, Hilde, Galibert, Marie-Dominique, Touati, Eliette
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Helicobacter Pylori
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456735/
https://ncbi.nlm.nih.gov/pubmed/31822580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2019-318640
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