Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis

BACKGROUND: Pyroptosis is a type of proinflammatory regulated cell death (RCD) in which caspase-1 proteolytically cleaves gasdermin D (GSDMD) to yield a cytotoxic pore-forming protein. Recent studies have suggested that additional cell death pathways may interact with GSDMD under certain circumstanc...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: McKenzie, Brienne A., Fernandes, Jason P., Doan, Matthew A. L., Schmitt, Laura M., Branton, William G., Power, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456507/
https://ncbi.nlm.nih.gov/pubmed/32861242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01902-5
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