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Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis
BACKGROUND: Pyroptosis is a type of proinflammatory regulated cell death (RCD) in which caspase-1 proteolytically cleaves gasdermin D (GSDMD) to yield a cytotoxic pore-forming protein. Recent studies have suggested that additional cell death pathways may interact with GSDMD under certain circumstanc...
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| Publicat a: | J Neuroinflammation |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7456507/ https://ncbi.nlm.nih.gov/pubmed/32861242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01902-5 |
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