Epigenetic loss of the transfer RNA-modifying enzyme TYW2 induces ribosome frameshifts in colon cancer

Transfer RNA (tRNA) activity is tightly regulated to provide a physiological protein translation, and tRNA chemical modifications control its function in a complex with ribosomes and messenger RNAs (mRNAs). In this regard, the correct hypermodification of position G37 of phenylalanine-tRNA, adjacent...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Rosselló-Tortella, Margalida, Llinàs-Arias, Pere, Sakaguchi, Yuriko, Miyauchi, Kenjyo, Davalos, Veronica, Setien, Fernando, Calleja-Cervantes, Maria E., Piñeyro, David, Martínez-Gómez, Jesús, Guil, Sonia, Joshi, Ricky, Villanueva, Alberto, Suzuki, Tsutomu, Esteller, Manel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2020
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456070/
https://ncbi.nlm.nih.gov/pubmed/32778592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003358117
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