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Engineering a far-red light–activated split-Cas9 system for remote-controlled genome editing of internal organs and tumors
It is widely understood that CRISPR-Cas9 technology is revolutionary, with well-recognized issues including the potential for off-target edits and the attendant need for spatiotemporal control of editing. Here, we describe a far-red light (FRL)–activated split-Cas9 (FAST) system that can robustly in...
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| Veröffentlicht in: | Sci Adv |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Association for the Advancement of Science
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7455487/ https://ncbi.nlm.nih.gov/pubmed/32923591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb1777 |
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