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Accumulation of collagen molecular unfolding is the mechanism of cyclic fatigue damage and failure in collagenous tissues

Overuse injuries to dense collagenous tissues are common, but their etiology is poorly understood. The predominant hypothesis that micro-damage accumulation exceeds the rate of biological repair is missing a mechanistic explanation. Here, we used collagen hybridizing peptides to measure collagen mol...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Adv
Hauptverfasser: Zitnay, Jared L., Jung, Gang Seob, Lin, Allen H., Qin, Zhao, Li, Yang, Yu, S. Michael, Buehler, Markus J., Weiss, Jeffrey A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7455178/
https://ncbi.nlm.nih.gov/pubmed/32923623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba2795
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