Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1

Macrolide antibiotics exert antiinflammatory effects; however, little is known regarding their immunomodulatory mechanisms. In this study, using 2 distinct mouse models of mucosal inflammatory disease (LPS-induced acute lung injury and ligature-induced periodontitis), we demonstrated that the antiin...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Maekawa, Tomoki, Tamura, Hikaru, Domon, Hisanori, Hiyoshi, Takumi, Isono, Toshihito, Yonezawa, Daisuke, Hayashi, Naoki, Takahashi, Naoki, Tabeta, Koichi, Maeda, Takeyasu, Oda, Masataka, Ziogas, Athanasios, Alexaki, Vasileia Ismini, Chavakis, Triantafyllos, Terao, Yutaka, Hajishengallis, George
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7455085/
https://ncbi.nlm.nih.gov/pubmed/32603314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136706
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