Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia

Excessive activation of neutrophils results in the release of neutrophil elastase (NE), which leads to lung injury in severe pneumonia. Previously, we demonstrated a novel immune subversion mechanism involving microbial exploitation of this NE ability, which eventually promotes disruption of the pul...

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Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Domon, Hisanori, Nagai, Kosuke, Maekawa, Tomoki, Oda, Masataka, Yonezawa, Daisuke, Takeda, Wataru, Hiyoshi, Takumi, Tamura, Hikaru, Yamaguchi, Masaya, Kawabata, Shigetada, Terao, Yutaka
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5996908/
https://ncbi.nlm.nih.gov/pubmed/29922273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00732
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