BET bromodomain proteins regulate transcriptional reprogramming in genetic dilated cardiomyopathy

The bromodomain and extraterminal (BET) family comprises epigenetic reader proteins that are important regulators of inflammatory and hypertrophic gene expression in the heart. We previously identified the activation of proinflammatory gene networks as a key early driver of dilated cardiomyopathy (D...

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Udgivet i:JCI Insight
Main Authors: Antolic, Andrew, Wakimoto, Hiroko, Jiao, Zhe, Gorham, Joshua M., DePalma, Steven R., Lemieux, Madeleine E., Conner, David A., Lee, Da Young, Qi, Jun, Seidman, Jonathan G., Bradner, James E., Brown, Jonathan D., Haldar, Saptarsi M., Seidman, Christine E., Burke, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7455078/
https://ncbi.nlm.nih.gov/pubmed/32603312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.138687
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