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Free light chains injure proximal tubule cells through the STAT1/HMGB1/TLR axis

Free light chains (FLCs) induce inflammatory pathways in proximal tubule cells (PTCs). The role of TLRs in these responses is unknown. Here we present findings on the role of TLRs in FLC-induced PTC injury. We exposed human kidney PTC cultures to κ and λ FLCs and used cell supernatants and pellets f...

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Publicado en:JCI Insight
Main Authors: Upadhyay, Rohit, Ying, Wei-Zhong, Nasrin, Zannatul, Safah, Hana, Jaimes, Edgar A., Feng, Wenguang, Sanders, Paul W., Batuman, Vecihi
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7453901/
https://ncbi.nlm.nih.gov/pubmed/32544092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.137191
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