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Free light chains injure proximal tubule cells through the STAT1/HMGB1/TLR axis

Free light chains (FLCs) induce inflammatory pathways in proximal tubule cells (PTCs). The role of TLRs in these responses is unknown. Here we present findings on the role of TLRs in FLC-induced PTC injury. We exposed human kidney PTC cultures to κ and λ FLCs and used cell supernatants and pellets f...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Upadhyay, Rohit, Ying, Wei-Zhong, Nasrin, Zannatul, Safah, Hana, Jaimes, Edgar A., Feng, Wenguang, Sanders, Paul W., Batuman, Vecihi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7453901/
https://ncbi.nlm.nih.gov/pubmed/32544092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.137191
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