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Free light chains injure proximal tubule cells through the STAT1/HMGB1/TLR axis
Free light chains (FLCs) induce inflammatory pathways in proximal tubule cells (PTCs). The role of TLRs in these responses is unknown. Here we present findings on the role of TLRs in FLC-induced PTC injury. We exposed human kidney PTC cultures to κ and λ FLCs and used cell supernatants and pellets f...
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| Publicado en: | JCI Insight |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7453901/ https://ncbi.nlm.nih.gov/pubmed/32544092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.137191 |
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