Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference

BACKGROUND: DNA methylation is a key epigenetic modification in human development and disease, yet there is limited understanding of its highly coordinated regulation. Here, we identify 818 genes that affect DNA methylation patterns in blood using large-scale population genomics data. RESULTS: By em...

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Foilsithe in:Genome Biol
Main Authors: Hop, Paul J., Luijk, René, Daxinger, Lucia, van Iterson, Maarten, Dekkers, Koen F., Jansen, Rick, van Meurs, Joyce B. J., ’t Hoen, Peter A. C., Ikram, M. Arfan, van Greevenbroek, Marleen M. J., Boomsma, Dorret I., Slagboom, P. Eline, Veldink, Jan H., van Zwet, Erik W., Heijmans, Bastiaan T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2020
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7453518/
https://ncbi.nlm.nih.gov/pubmed/32859263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02114-z
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