Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference

BACKGROUND: DNA methylation is a key epigenetic modification in human development and disease, yet there is limited understanding of its highly coordinated regulation. Here, we identify 818 genes that affect DNA methylation patterns in blood using large-scale population genomics data. RESULTS: By em...

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Enregistré dans:
Détails bibliographiques
Publié dans:Genome Biol
Auteurs principaux: Hop, Paul J., Luijk, René, Daxinger, Lucia, van Iterson, Maarten, Dekkers, Koen F., Jansen, Rick, van Meurs, Joyce B. J., ’t Hoen, Peter A. C., Ikram, M. Arfan, van Greevenbroek, Marleen M. J., Boomsma, Dorret I., Slagboom, P. Eline, Veldink, Jan H., van Zwet, Erik W., Heijmans, Bastiaan T.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7453518/
https://ncbi.nlm.nih.gov/pubmed/32859263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02114-z
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