Discovery of human coronaviruses pan-papain-like protease inhibitors using computational approaches

The papain-like protease (PL(pro)) is vital for the replication of coronaviruses (CoVs), as well as for escaping innate-immune responses of the host. Hence, it has emerged as an attractive antiviral drug-target. In this study, computational approaches were employed, mainly the structure-based virtua...

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Veröffentlicht in:J Pharm Anal
Hauptverfasser: Alamri, Mubarak A., Tahir ul Qamar, Muhammad, Mirza, Muhammad Usman, Alqahtani, Safar M., Froeyen, Matheus, Chen, Ling-Ling
Format: Artigo
Sprache:Inglês
Veröffentlicht: Xi'an Jiaotong University 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7453225/
https://ncbi.nlm.nih.gov/pubmed/32874702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpha.2020.08.012
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