Adenosine-to-Inosine Editing of Vasoactive MicroRNAs Alters Their Targetome and Function in Ischemia

Adenosine-to-inosine (A-to-I) editing in the seed sequence of microRNAs can shift the microRNAs’ targetomes and thus their function. Using public RNA-sequencing data, we identified 35 vasoactive microRNAs that are A-to-I edited. We quantified A-to-I editing of the primary (pri-)microRNAs in vascular...

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Publicat a:Mol Ther Nucleic Acids
Autors principals: van der Kwast, Reginald V.C.T., Parma, Laura, van der Bent, M. Leontien, van Ingen, Eva, Baganha, Fabiana, Peters, Hendrika A.B., Goossens, Eveline A.C., Simons, Karin H., Palmen, Meindert, de Vries, Margreet R., Quax, Paul H.A., Nossent, A. Yaël
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7452086/
https://ncbi.nlm.nih.gov/pubmed/32814251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.07.020
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