Immunohistochemical scoring of CD38 in the tumor microenvironment predicts responsiveness to anti-PD-1/PD-L1 immunotherapy in hepatocellular carcinoma

INTRODUCTION: Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-associated mortality globally. Immune-checkpoint blockade (ICB) is one of the systemic therapy options for HCC. However, response rates remain low, necessitating robust predictive biomarkers. In the present study, we...

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Publicado no:J Immunother Cancer
Main Authors: Ng, Harry Ho Man, Lee, Ren Yuan, Goh, Siting, Tay, Isabel Shu Ying, Lim, Xinru, Lee, Bernett, Chew, Valerie, Li, Huihua, Tan, Benedict, Lim, Sherlly, Lim, Jeffrey Chun Tatt, Au, Bijin, Loh, Josh Jie Hua, Saraf, Sahil, Connolly, John Edward, Loh, Tracy, Leow, Wei Qiang, Lee, Joycelyn Jie Xin, Toh, Han Chong, Malavasi, Fabio, Lee, Ser Yee, Chow, Pierce, Newell, Evan W, Choo, Su Pin, Tai, David, Yeong, Joe, Lim, Tony Kiat Hon
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Basic Tumor Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7451957/
https://ncbi.nlm.nih.gov/pubmed/32847986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000987
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