TGF-β Orchestrates Fibrogenic and Developmental EMTs via RAS Effector RREB1

Epithelial-to-mesenchymal transitions (EMT) are phenotypic plasticity processes that confer migratory and invasive properties to epithelial cells during development, wound-healing, fibrosis and cancer(1–4). EMTs are driven by SNAIL, ZEB and TWIST transcription factors(5,6) together with micro-RNAs t...

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Veröffentlicht in:Nature
Hauptverfasser: Su, Jie, Morgani, Sophie M., David, Charles J., Wang, Qiong, Er, Ekrem Emrah, Huang, Yun-Han, Basnet, Harihar, Zou, Yilong, Shu, Weiping, Soni, Rajesh K., Hendrickson, Ronald C., Hadjantonakis, Anna-Katerina, Massagué, Joan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450666/
https://ncbi.nlm.nih.gov/pubmed/31915377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1897-5
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