Pre-existing immunity to influenza virus hemagglutinin stalk might drive selection for antibody-escape mutant viruses in a human challenge model

The conserved region of influenza hemagglutinin (HA) stalk (or stem) has gained attention as a potent target for universal influenza vaccines(1–5). Although the HA stalk region is relatively well conserved, the evolutionarily dynamic nature of influenza viruses(6) raises concerns about the possible...

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Publicado no:Nat Med
Main Authors: Park, Jae-Keun, Xiao, Yongli, Ramuta, Mitchell D., Rosas, Luz Angela, Fong, Sharon, Matthews, Alexis M., Freeman, Ashley D., Gouzoulis, Monica A., Batchenkova, Natalia A., Yang, Xingdong, Scherler, Kelsey, Qi, Li, Reed, Susan, Athota, Rani, Czajkowski, Lindsay, Han, Alison, Morens, David M., Walters, Kathie-Anne, Memoli, Matthew J., Kash, John C., Taubenberger, Jeffery K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450362/
https://ncbi.nlm.nih.gov/pubmed/32601336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-020-0937-x
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