Pre-existing immunity to influenza virus hemagglutinin stalk might drive selection for antibody-escape mutant viruses in a human challenge model

The conserved region of influenza hemagglutinin (HA) stalk (or stem) has gained attention as a potent target for universal influenza vaccines(1–5). Although the HA stalk region is relatively well conserved, the evolutionarily dynamic nature of influenza viruses(6) raises concerns about the possible...

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Pubblicato in:Nat Med
Autori principali: Park, Jae-Keun, Xiao, Yongli, Ramuta, Mitchell D., Rosas, Luz Angela, Fong, Sharon, Matthews, Alexis M., Freeman, Ashley D., Gouzoulis, Monica A., Batchenkova, Natalia A., Yang, Xingdong, Scherler, Kelsey, Qi, Li, Reed, Susan, Athota, Rani, Czajkowski, Lindsay, Han, Alison, Morens, David M., Walters, Kathie-Anne, Memoli, Matthew J., Kash, John C., Taubenberger, Jeffery K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450362/
https://ncbi.nlm.nih.gov/pubmed/32601336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-020-0937-x
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