Evidence Supporting the Safety of Pegylated Diethylaminoethyl-Chitosan Polymer as a Nanovector for Gene Therapy Applications

PURPOSE: Diethylaminoethyl-chitosan (DEAE-CH) is a derivative with excellent potential as a delivery vector for gene therapy applications. The aim of this study is to evaluate its toxicological profile for potential future clinical applications. METHODS: An endotoxin-free chitosan (CH) modified with...

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Pubblicato in:Int J Nanomedicine
Autori principali: Rondon, Elsa Patricia, Benabdoun, Houda Abir, Vallières, Francis, Segalla Petrônio, Maicon, Tiera, Marcio José, Benderdour, Mohamed, Fernandes, Julio Cesar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove 2020
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450204/
https://ncbi.nlm.nih.gov/pubmed/32922001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S252397
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