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The Influence of Polymer Topology on Pharmacokinetics: Differences Between Cyclic and Linear PEGylated Poly(acrylic Acid) Comb Polymers

Water-soluble polymers for the delivery of chemotherapeutic drugs passively target solid tumors as a consequence of reduced renal clearance and the enhanced permeation and retention (EPR) effect. Elimination of the polymers in the kidney occurs due to filtration through biological nanopores with a h...

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Bibliografski detalji
Glavni autori: Chen, Bo, Jerger, Katherine, Fréchet, Jean M. J., Szoka, Francis C.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788102/
https://ncbi.nlm.nih.gov/pubmed/19465070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2009.05.021
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