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The WD40-repeat protein WDR-48 promotes the stability of the deubiquitinating enzyme USP-46 by inhibiting its ubiquitination and degradation

Ubiquitination is a reversible post-translational modification that has emerged as a critical regulator of synapse development and function. However, the mechanisms that regulate the deubiquitinating enzymes (DUBs) responsible for the removal of ubiquitin from target proteins are poorly understood....

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hodul, Molly, Ganji, Rakesh, Dahlberg, Caroline L., Raman, Malavika, Juo, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450142/
https://ncbi.nlm.nih.gov/pubmed/32587090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014590
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