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PRL3 pseudophosphatase activity is necessary and sufficient to promote metastatic growth

Phosphatases of regenerating liver (PRLs) are markers of cancer and promote tumor growth. They have been implicated in a variety of biochemical pathways but the physiologically relevant target of phosphatase activity has eluded 20 years of investigation. Here, we show that PRL3 catalytic activity is...

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Publicat a:J Biol Chem
Autors principals: Kozlov, Guennadi, Funato, Yosuke, Chen, Yu Seby, Zhang, Zhidian, Illes, Katalin, Miki, Hiroaki, Gehring, Kalle
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450121/
https://ncbi.nlm.nih.gov/pubmed/32571875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014464
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