5′-UTR recruitment of the translation initiation factor eIF4GI or DAP5 drives cap-independent translation of a subset of human mRNAs

During unfavorable conditions (e.g. tumor hypoxia or viral infection), canonical, cap-dependent mRNA translation is suppressed in human cells. Nonetheless, a subset of physiologically important mRNAs (e.g. hypoxia-inducible factor 1α [HIF-1α], fibroblast growth factor 9 [FGF-9], and p53) is still tr...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Haizel, Solomon A., Bhardwaj, Usha, Gonzalez, Ruben L., Mitra, Somdeb, Goss, Dixie J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2020
Aiheet:
Gene Regulation
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450097/
https://ncbi.nlm.nih.gov/pubmed/32571876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013678
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