Y772 phosphorylation of EphA2 is responsible for EphA2-dependent NPC nasopharyngeal carcinoma growth by Shp2/Erk-1/2 signaling pathway

EphA2 is an important oncogenic protein and emerging drug target, but the oncogenic role and mechanism of ligand-independent phosphorylation of EphA2 at tyrosine 772 (pY772-EphA2) is unclear. In this study, we established nasopharyngeal carcinoma (NPC) cell lines with stable expression of exogenous...

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Udgivet i:Cell Death Dis
Main Authors: Xiang, Yi-Ping, Xiao, Ta, Li, Qi-Guang, Lu, Shan-Shan, Zhu, Wei, Liu, Yun-Ya, Qiu, Jie-Ya, Song, Zheng-Hui, Huang, Wei, Yi, Hong, Tang, Yao-Yun, Xiao, Zhi-Qiang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449971/
https://ncbi.nlm.nih.gov/pubmed/32848131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02831-0
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