Extracellular SPARC cooperates with TGF-β signalling to induce pro-fibrotic activation of systemic sclerosis patient dermal fibroblasts

OBJECTIVES: SSc is an autoimmune disease characterized by inflammation, vascular injury and excessive fibrosis in multiple organs. Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein that regulates processes involved in SSc pathology, such as inflammation and fibrosi...

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Publicado en:Rheumatology (Oxford)
Autores principales: Carvalheiro, Tiago, Malvar Fernández, Beatriz, Ottria, Andrea, Giovannone, Barbara, Marut, Wioleta, Reedquist, Kris A, Garcia, Samuel, Radstake, Timothy R
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Clinical Science
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449812/
https://ncbi.nlm.nih.gov/pubmed/31840182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/kez583
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