Cefazolin Inoculum Effect and Methicillin-Susceptible Staphylococcus aureus Osteoarticular Infections in Children

Select methicillin-susceptible Staphylococcus aureus (MSSA) strains may produce β-lactamases with affinity for first-generation cephalosporins (1GCs). In the setting of a high inoculum, these β-lactamases may promote the cleavage of 1GCs, a phenomenon known as the cefazolin inoculum effect (CzIE). W...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: McNeil, J. Chase, Sommer, Lauren M., Boyle, Mary, Hogan, Patrick, Vallejo, Jesus G., Hultén, Kristina G., Flores, Anthony R., Kaplan, Sheldon L., Fritz, Stephanie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Epidemiology and Surveillance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449214/
https://ncbi.nlm.nih.gov/pubmed/32660989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00703-20
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