CRISPR-Cas9-Mediated Carbapenemase Gene and Plasmid Curing in Carbapenem-Resistant Enterobacteriaceae

Combating plasmid-mediated carbapenem resistance is essential to control and prevent the dissemination of carbapenem-resistant Enterobacteriaceae (CRE). Here, we conducted a proof-of-concept study to demonstrate that CRISPR-Cas9-mediated resistance gene and plasmid curing can effectively resensitize...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Hao, Mingju, He, Yuzhang, Zhang, Haifang, Liao, Xiao-Ping, Liu, Ya-Hong, Sun, Jian, Du, Hong, Kreiswirth, Barry N., Chen, Liang
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449206/
https://ncbi.nlm.nih.gov/pubmed/32631827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00843-20
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