A new mechanism for a familiar mutation – bovine DGAT1 K232A modulates gene expression through multi-junction exon splice enhancement

BACKGROUND: The DGAT1 gene encodes an enzyme responsible for catalysing the terminal reaction in mammary triglyceride synthesis, and underpins a well-known pleiotropic quantitative trait locus (QTL) with a large influence on milk composition phenotypes. Since first described over 15 years ago, a pro...

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Détails bibliographiques
Publié dans:BMC Genomics
Auteurs principaux: Fink, Tania, Lopdell, Thomas J., Tiplady, Kathryn, Handley, Renee, Johnson, Thomas J. J., Spelman, Richard J., Davis, Stephen R., Snell, Russell G., Littlejohn, Mathew D.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449055/
https://ncbi.nlm.nih.gov/pubmed/32847516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-020-07004-z
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