Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans

The formation of mammalian dendritic cells (DCs) is controlled by multiple hematopoietic transcription factors, including IRF8. Loss of IRF8 exerts a differential effect on DC subsets, including plasmacytoid DCs (pDCs) and the classical DC lineages cDC1 and cDC2. In humans, cDC2-related subsets have...

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Опубликовано в: :Immunity
Главные авторы: Cytlak, Urszula, Resteu, Anastasia, Pagan, Sarah, Green, Kile, Milne, Paul, Maisuria, Sheetal, McDonald, David, Hulme, Gillian, Filby, Andrew, Carpenter, Benjamin, Queen, Rachel, Hambleton, Sophie, Hague, Rosie, Lango Allen, Hana, Thaventhiran, James E.D., Doody, Gina, Collin, Matthew, Bigley, Venetia
Формат: Artigo
Язык:Inglês
Опубликовано: Cell Press 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447982/
https://ncbi.nlm.nih.gov/pubmed/32735845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.07.003
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