Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans

The formation of mammalian dendritic cells (DCs) is controlled by multiple hematopoietic transcription factors, including IRF8. Loss of IRF8 exerts a differential effect on DC subsets, including plasmacytoid DCs (pDCs) and the classical DC lineages cDC1 and cDC2. In humans, cDC2-related subsets have...

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Gepubliceerd in:Immunity
Hoofdauteurs: Cytlak, Urszula, Resteu, Anastasia, Pagan, Sarah, Green, Kile, Milne, Paul, Maisuria, Sheetal, McDonald, David, Hulme, Gillian, Filby, Andrew, Carpenter, Benjamin, Queen, Rachel, Hambleton, Sophie, Hague, Rosie, Lango Allen, Hana, Thaventhiran, James E.D., Doody, Gina, Collin, Matthew, Bigley, Venetia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447982/
https://ncbi.nlm.nih.gov/pubmed/32735845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.07.003
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