The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates

Meiotic recombination proceeds via binding of RPA, RAD51, and DMC1 to single-stranded DNA (ssDNA) substrates created after formation of programmed DNA double-strand breaks. Here we report high-resolution in vivo maps of RPA and RAD51 in meiosis, mapping their binding locations and lifespans to indiv...

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發表在:Mol Cell
Main Authors: Hinch, Anjali Gupta, Becker, Philipp W., Li, Tao, Moralli, Daniela, Zhang, Gang, Bycroft, Clare, Green, Catherine, Keeney, Scott, Shi, Qinghua, Davies, Benjamin, Donnelly, Peter
格式: Artigo
語言:Inglês
出版: Cell Press 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447979/
https://ncbi.nlm.nih.gov/pubmed/32610038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.06.015
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