Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models

We herein report the synthesis, antioxidant power and neuroprotective properties of nine homo-bis-nitrones HBNs 1–9 as alpha-phenyl-N-tert-butylnitrone (PBN) analogues for stroke therapy. In vitro neuroprotection studies of HBNs 1–9 against Oligomycin A/Rotenone and in an oxygen-glucose-deprivation...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Chamorro, Beatriz, Diez-Iriepa, Daniel, Merás-Sáiz, Belén, Chioua, Mourad, García-Vieira, David, Iriepa, Isabel, Hadjipavlou-Litina, Dimitra, López-Muñoz, Francisco, Martínez-Murillo, Ricardo, Gonzàlez-Nieto, Daniel, Fernández, Israel, Marco-Contelles, José, Oset-Gasque, María Jesús
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447640/
https://ncbi.nlm.nih.gov/pubmed/32843666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70690-y
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