Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models

We herein report the synthesis, antioxidant power and neuroprotective properties of nine homo-bis-nitrones HBNs 1–9 as alpha-phenyl-N-tert-butylnitrone (PBN) analogues for stroke therapy. In vitro neuroprotection studies of HBNs 1–9 against Oligomycin A/Rotenone and in an oxygen-glucose-deprivation...

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Publicado no:Sci Rep
Main Authors: Chamorro, Beatriz, Diez-Iriepa, Daniel, Merás-Sáiz, Belén, Chioua, Mourad, García-Vieira, David, Iriepa, Isabel, Hadjipavlou-Litina, Dimitra, López-Muñoz, Francisco, Martínez-Murillo, Ricardo, Gonzàlez-Nieto, Daniel, Fernández, Israel, Marco-Contelles, José, Oset-Gasque, María Jesús
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447640/
https://ncbi.nlm.nih.gov/pubmed/32843666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70690-y
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