Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis

Endothelial Tie2 signaling plays a pivotal role in vascular barrier maintenance at baseline and after injury. We previously demonstrated that a sharp drop in Tie2 expression observed across various murine models of critical illnesses is associated with increased vascular permeability and mortality....

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Idowu, Temitayo O, Etzrodt, Valerie, Seeliger, Benjamin, Bolanos-Palmieri, Patricia, Thamm, Kristina, Haller, Hermann, David, Sascha
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Immunology and Inflammation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447424/
https://ncbi.nlm.nih.gov/pubmed/32838837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.59520
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