Differential activation of the transcription factor IRF1 underlies the distinct immune responses elicited by type I and type III interferons

Type I and III interferons (IFNs) activate similar downstream signaling cascades but unlike type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here we examined the molecular mechanisms underlying this disparity. Type I and III IFNs displayed kinetic differences in...

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Pubblicato in:Immunity
Autori principali: Forero, Adriana, Ozarkar, Snehal, Li, Hongchuan, Lee, Chia Heng, Hemann, Emily A., Nadjsombati, Marija S., Hendricks, Matthew R., So, Lomon, Green, Richard, Roy, Chandra N., Sarkar, Saumendra N., von Moltke, Jakob, Anderson, Stephen K., Gale, Michael, Savan, Ram
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447158/
https://ncbi.nlm.nih.gov/pubmed/31471108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.07.007
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