Differential activation of the transcription factor IRF1 underlies the distinct immune responses elicited by type I and type III interferons

Type I and III interferons (IFNs) activate similar downstream signaling cascades but unlike type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here we examined the molecular mechanisms underlying this disparity. Type I and III IFNs displayed kinetic differences in...

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Bibliografiska uppgifter
I publikationen:Immunity
Huvudupphovsmän: Forero, Adriana, Ozarkar, Snehal, Li, Hongchuan, Lee, Chia Heng, Hemann, Emily A., Nadjsombati, Marija S., Hendricks, Matthew R., So, Lomon, Green, Richard, Roy, Chandra N., Sarkar, Saumendra N., von Moltke, Jakob, Anderson, Stephen K., Gale, Michael, Savan, Ram
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447158/
https://ncbi.nlm.nih.gov/pubmed/31471108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.07.007
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