Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother–infant pairs

BACKGROUND: Many maternal traits are associated with a neonate’s gestational duration, birth weight, and birth length. These birth outcomes are subsequently associated with late-onset health conditions. The causal mechanisms and the relative contributions of maternal and fetal genetic effects behind...

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Veröffentlicht in:PLoS Med
Hauptverfasser: Chen, Jing, Bacelis, Jonas, Sole-Navais, Pol, Srivastava, Amit, Juodakis, Julius, Rouse, Amy, Hallman, Mikko, Teramo, Kari, Melbye, Mads, Feenstra, Bjarke, Freathy, Rachel M., Smith, George Davey, Lawlor, Deborah A., Murray, Jeffrey C., Williams, Scott M., Jacobsson, Bo, Muglia, Louis J., Zhang, Ge
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447062/
https://ncbi.nlm.nih.gov/pubmed/32841251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003305
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