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Improved Antitumor Efficacy of Chimeric Antigen Receptor T Cells that Secrete Single-Domain Antibody Fragments

Chimeric antigen receptor (CAR) T-cell therapy is effective in the treatment of cancers of hematopoietic origin. In the immunosuppressive solid tumor environment, CAR T cells encounter obstacles that compromise their efficacy. We developed a strategy to address these barriers by having CAR T cells s...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Xie, Yushu Joy, Dougan, Michael, Ingram, Jessica R., Pishesha, Novalia, Fang, Tao, Momin, Noor, Ploegh, Hidde L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446749/
https://ncbi.nlm.nih.gov/pubmed/32019780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0734
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