A Single Human V(H)-gene Allows for a Broad-Spectrum Antibody Response Targeting Bacterial Lipopolysaccharides in the Blood

B cell receptors (BCRs) display a combination of variable (V)-gene-encoded complementarity determining regions (CDRs) and adaptive/hypervariable CDR3 loops to engage antigens. It has long been proposed that the former tune for recognition of pathogens or groups of pathogens. To experimentally evalua...

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Pubblicato in:Cell Rep
Autori principali: Sangesland, Maya, Yousif, Ashraf S., Ronsard, Larance, Kazer, Samuel W., Zhu, Alex Lee, Gatter, G. James, Hayward, Matthew R., Barnes, Ralston M., Quirindongo-Crespo, Maricel, Rohrer, Daniel, Lonberg, Nils, Kwon, Douglas, Shalek, Alex K., Lingwood, Daniel
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Author(s). 2020
Soggetti:
Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446668/
https://ncbi.nlm.nih.gov/pubmed/32846123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108065
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