Pathogenic Variants in CHEK2 Are Associated With an Adverse Prognosis in Symptomatic Early-Onset Breast Cancer

PURPOSE: Checkpoint kinase 2 (CHEK2) is frequently included in multigene panels. We describe the associated outcomes among carriers of CHEK2 pathogenic variants in young patients with symptomatic breast cancer. PATIENTS AND METHODS: Participants (N = 2,344) in the Prospective Outcomes in Sporadic Ve...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Greville-Heygate, Stephanie L., Maishman, Tom, Tapper, William J., Cutress, Ramsey I., Copson, Ellen, Dunning, Alison M., Haywood, Linda, Jones, Louise J., Eccles, Diana M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2020
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446368/
https://ncbi.nlm.nih.gov/pubmed/32923877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.19.00178
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