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New somatic TERT promoter variants enhance the Telomerase activity in Glioblastoma
The catalytic activity of human Telomerase Reverse Transcriptase (TERT) compensates for the loss of telomere length, eroded during each cell cycle, to ensure a correct division of stem and germinal cells. In human tumors, ectopic TERT reactivation, most frequently due to hotspot mutations in the pro...
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| Publicado no: | Acta Neuropathol Commun |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7445914/ https://ncbi.nlm.nih.gov/pubmed/32843091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01022-4 |
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