New somatic TERT promoter variants enhance the Telomerase activity in Glioblastoma

The catalytic activity of human Telomerase Reverse Transcriptase (TERT) compensates for the loss of telomere length, eroded during each cell cycle, to ensure a correct division of stem and germinal cells. In human tumors, ectopic TERT reactivation, most frequently due to hotspot mutations in the pro...

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Bibliografische gegevens
Gepubliceerd in:Acta Neuropathol Commun
Hoofdauteurs: Pierini, Tiziana, Nardelli, Carlotta, Lema Fernandez, Anair Graciela, Pierini, Valentina, Pellanera, Fabrizia, Nofrini, Valeria, Gorello, Paolo, Moretti, Martina, Arniani, Silvia, Roti, Giovanni, Giovenali, Paolo, Lupattelli, Marco, Metro, Giulio, Molica, Carmen, Castrioto, Corrado, Corinaldesi, Rodolfo, Laurenti, Maria Elena, Ascani, Stefano, Mecucci, Cristina, La Starza, Roberta
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2020
Onderwerpen:
Case Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7445914/
https://ncbi.nlm.nih.gov/pubmed/32843091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01022-4
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