Hypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-the-art in vitro and mouse infection models

Hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC) worldwide. The prolyl hydroxylase domain (PHD)-hypoxia inducible factor (HIF) pathway is a key mammalian oxygen sensing pathway and is frequently perturbed by pathological states including infection and inflammation. We d...

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Publicado no:Sci Rep
Main Authors: Liu, Peter Jianrui, Harris, James M., Marchi, Emanuele, D’Arienzo, Valentina, Michler, Thomas, Wing, Peter A. C., Magri, Andrea, Ortega-Prieto, Anna Maria, van de Klundert, Maarten, Wettengel, Jochen, Durantel, David, Dorner, Marcus, Klenerman, Paul, Protzer, Ulrike, Giotis, Efstathios S., McKeating, Jane A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7445281/
https://ncbi.nlm.nih.gov/pubmed/32839523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70865-7
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