Impacts of CYP2C19 genetic polymorphisms on bioavailability and effect on platelet adhesion of vicagrel, a novel thienopyridine P2Y(12) inhibitor

AIMS: We investigated the impacts of CYP2C19 polymorphisms on pharmacokinetics and pharmacodynamics of vicagrel in healthy Chinese subjects. METHODS: CYP2C19 extensive metabolizers (EMs), intermediate metabolizers (IMs) and poor metabolizers (PMs; 16 subjects/group) participated in a randomized, ope...

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Bibliografski detalji
Izdano u:Br J Clin Pharmacol
Glavni autori: Zhang, Yifan, Zhu, Xiaoxue, Zhan, Yan, Li, Xiaojiao, Liu, Cai, Zhu, Yunting, Zhang, Hong, Wei, Haijing, Xia, Yu, Sun, Hongbin, Liu, Yongqiang, Lai, Xiaojuan, Gong, Yanchun, Liu, Xuefang, Li, Yongguo, Ding, Yanhua, Zhong, Dafang
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7444798/
https://ncbi.nlm.nih.gov/pubmed/32267573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14296
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