Expression analysis and significance of PD-1, LAG-3 and TIM-3 in human non-small cell lung cancer using spatially-resolved and multiparametric single-cell analysis.

PURPOSE: To determine the tumor tissue/cell distribution, functional associations and clinical significance of PD-1, LAG-3 and TIM-3 protein expression in human non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN: Using multiplexed quantitative immunofluorescence (QIF), we performed localized me...

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Publicat a:Clin Cancer Res
Autors principals: Datar, Ila, Sanmamed, Miguel F., Wang, Jun, Henick, Brian S., Choi, Jungmin, Badri, Ti, Dong, Weilai, Mani, Nikita, Toki, Maria, Mejías, Luis D, Lozano, Maria D, Perez-Gracia, Jose Luis, Velcheti, Vamsidhar, Hellmann, Matthew D., Gainor, Justin F., McEachern, Kristen, Jenkins, David, Syrigos, Konstantinos, Politi, Katerina, Gettinger, Scott, Rimm, David L, Herbst, Roy S., Melero, Ignacio, Chen, Lieping, Schalper, Kurt A.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7444693/
https://ncbi.nlm.nih.gov/pubmed/31053602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-4142
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